Effect of induced metabolic alkalosis on sweat composition in men
- 22 January 2002
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 174 (1), 41-46
- https://doi.org/10.1046/j.1365-201x.2002.00927.x
Abstract
To determine whether induced metabolic alkalosis affects sweat composition, 10 males cycled for 90 min at 62.5 ± 1.3% peak oxygen uptake, on two separate occasions. Subjects ingested either empty capsules (placebo) or capsules containing NaHCO3– (0.3 g kg–1 body mass; six equal doses) over a 2-h period, which commenced 3 h prior to exercise. Arterialized-venous blood samples were drawn prior to and after 15, 30, 60 and 90 min of exercise. Sweat was aspirated at the end of exercise from a patch located on the right scapula region. NaHCO3– ingestion elevated blood pH, [HCO3–] and serum [Na+], whereas serum [Cl–] and [K+] were reduced, both at rest and during exercise (P < 0.05). Sweat pH was greater in the NaHCO3– trial (6.24 ± 0.18 vs. 6.38 ± 0.18; P < 0.05), whereas sweat [Na+] (49.5 ± 4.8 vs. 50.2 ± 4.3 mEq L–1), [Cl–] (37.5 ± 5.1 vs. 39.3 ± 4.2 mEq L–1) and [K+] (4.66 ± 0.19 vs. 4.64 ± 0.34 mEq L–1) did not differ between trials (P > 0.05). Sweat [HCO3–] (2.49 ± 0.58 vs. 3.73 ± 1.10 mEq L–1) and [lactate] (8.92 ± 0.79 vs. 10.51 ± 0.32 mmol L–1) tended to be greater after NaHCO3– ingestion, although significance was not reached (P=0.07 and P=0.08, respectively). These data indicate that induced metabolic alkalosis can modify sweat composition, although it is unclear whether the secretory coil, reabsorptive duct, or both are responsible for this alteration.Keywords
This publication has 18 references indexed in Scilit:
- Variations in Regional Sweat Composition in Normal Human MalesExperimental Physiology, 2000
- Effects of High and Low Blood Lactate Concentrations on Sweat Lactate ResponseInternational Journal of Sports Medicine, 2000
- A simple and disposable sweat collectorEuropean Journal of Applied Physiology, 1991
- Intracellular potassium activity and the role of potassium in transepithelial salt transport in the human reabsorptive sweat ductThe Journal of Membrane Biology, 1991
- Cl‐ Conductance and Acid Secretion in the Human Sweat DuctAnnals of the New York Academy of Sciences, 1989
- Measured and derived quantities with modern pH and blood gas equipment: Calculation algorithms with 54 equationsScandinavian Journal of Clinical and Laboratory Investigation, 1988
- A simple, rapid method for the determination of glucose, lactate, pyruvate, alanine, 3-hydroxybutyrate and acetoacetate on a single 20-μl blood sampleClinica Chimica Acta; International Journal of Clinical Chemistry, 1982
- Hydrogen ion and electrolyte excretion of the single human sweat glandPflügers Archiv - European Journal of Physiology, 1974
- Regional and Individual Variations in the Function of the Human Eccrine Sweat GlandJournal of Investigative Dermatology, 1970
- Intracellular Acid-Base Regulation. I. The Response of Muscle Cells to Changes in CO2 Tension or Extracellular Bicarbonate Concentration *JCI Insight, 1965