Pain
- 4 October 2012
- journal article
- research article
- Published by Wiley in WIREs Cognitive Science
- Vol. 4 (1), 1-15
- https://doi.org/10.1002/wcs.1201
Abstract
Pain has many valuable functions. It often signals injury or disease, generates a wide range of adaptive behaviors, and promotes healing through rest. Despite these beneficial aspects of pain, there are negative features that challenge our understanding of the puzzle of pain, including persistent phantom limb pain after amputation or total spinal cord transection. Pain is a personal, subjective experience influenced by cultural learning, the meaning of the situation, attention, and other psychological variables. Pain processes do not begin with the stimulation of receptors. Rather, injury or disease produces neural signals that enter an active nervous system that (in the adult organism) is the substrate of past experience, culture, and a host of other environmental and personal factors. These brain processes actively participate in the selection, abstraction, and synthesis of information from the total sensory input. Pain is not simply the end product of a linear sensory transmission system; it is a dynamic process that involves continuous interactions among complex ascending and descending systems. The neuromatrix theory guides us away from the Cartesian concept of pain as a sensation produced by injury, inflammation, or other tissue pathology and toward the concept of pain as a multidimensional experience produced by multiple influences. These influences range from the existing synaptic architecture of the neuromatrix—which is determined by genetic and sensory factors—to influences from within the body and from other areas in the brain. Genetic influences on synaptic architecture may determine—or predispose toward—the development of chronic pain syndromes. WIREs Cogn Sci 2013, 4:1–15. doi: 10.1002/wcs.1201 This article is categorized under:Keywords
This publication has 67 references indexed in Scilit:
- An eight-week yoga intervention is associated with improvements in pain, psychological functioning and mindfulness, and changes in cortisol levels in women with fibromyalgiaJournal of Pain Research, 2011
- Chronic Pain as a Disease in its Own RightPain Practice, 2004
- Unilateral nerve injury produces bilateral loss of distal innervationAnnals of Neurology, 2004
- Postoperative Morphine Use and Hyperalgesia Are Reduced by Preoperative but Not Intraoperative Epidural AnalgesiaAnesthesiology, 2003
- Unilateral postherpetic neuralgia is associated with bilateral sensory neuron damageAnnals of Neurology, 1998
- High dose alfentanil pre-empts pain after abdominal hysterectomyPain, 1996
- The Charles Bonnet Syndrome: ‘Phantom Visual Images’Perception, 1991
- Phantom limbs and the concept of a neuromatrixTrends in Neurosciences, 1990
- Psychogenic/idiopathic pain syndromesGeneral Hospital Psychiatry, 1987
- Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neuronesBrain Research, 1982