Toll-like Receptor 4 and Hepatic Fibrogenesis
- 21 July 2010
- journal article
- review article
- Published by Georg Thieme Verlag KG in Seminars in Liver Disease
- Vol. 30 (03), 232-244
- https://doi.org/10.1055/s-0030-1255353
Abstract
Inflammation is strongly associated with chronic hepatic injury and the ensuing wound-healing process. Recent evidence from mouse models and human studies implicates Toll-like receptors (TLRs) as important regulators of the inflammatory response and a functional link between inflammation and fibrosis in the chronically injured liver. Here, we review mechanisms by which TLR4 and TLR4 ligands from the intestinal microbiota contribute to hepatic injury, inflammation, hepatic stellate cell activation, and fibrosis.This publication has 99 references indexed in Scilit:
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