Interplay of Oxidants and Antioxidants During Exercise: Implications for Muscle Health
- 1 December 2009
- journal article
- review article
- Published by Taylor & Francis Ltd in The Physician and Sportsmedicine
- Vol. 37 (4), 116-123
- https://doi.org/10.3810/psm.2009.12.1749
Abstract
Muscle contraction results in generation of reactive oxygen and nitrogen species (RONS) at a rate determined by the intensity, frequency, and duration of the exercise protocols. Strenuous exercise causes oxidation of protein, lipid, and DNA, release of cytosolic enzymes, and other signs of cell damage; however, only exhaustive exercise is detrimental. Indeed, the regulation of vascular tone, the excitation-contraction coupling, growth, and differentiation in skeletal muscle, are governed in part by RONS. This is accomplished by RONS interaction with redox-sensitive transcription factors, leading to increased gene expression of antioxidant enzymes, cytoprotective proteins, and other enzymes involved in muscle metabolic functions. However, high levels of RONS generation are known to cause oxidative stress, activate certain pathogenic pathways, and accelerate aging. This article reviews research from the past decades on the interplay of oxidants and antioxidants in skeletal muscle, with particular reference to increased contractile activity. Adaptation of muscle to increased oxidative stress and the potential mechanisms involved will be highlighted. The role of redox-controlled cell signaling in skeletal muscle health and function is also described.Keywords
This publication has 67 references indexed in Scilit:
- Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force ProductionPhysiological Reviews, 2008
- RETRACTED: Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer researchToxicology, 2007
- Microdialysis studies of extracellular reactive oxygen species in skeletal muscle: Factors influencing the reduction of cytochrome c and hydroxylation of salicylateFree Radical Biology & Medicine, 2005
- Release of reactive oxygen and nitrogen species from contracting skeletal muscle cellsFree Radical Biology & Medicine, 2004
- Allopurinol and Markers of Muscle Damage Among Participants in the Tour de FranceJama-Journal Of The American Medical Association, 2003
- Oxidative stress indices: analytical aspects and significancePublished by Elsevier BV ,2000
- The definition and measurement of antioxidants in biological systemsFree Radical Biology & Medicine, 1995
- Oxidative stress: damage to intact cells and organsPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982
- Free Radicals in Biological MaterialsNature, 1954