Future Research Directions in Sleep and ADHD
- 13 September 2012
- journal article
- review article
- Published by SAGE Publications in Journal of Attention Disorders
- Vol. 17 (7), 550-564
- https://doi.org/10.1177/1087054712457992
Abstract
Objective: To explore relationships between basic and translational science research regarding sleep and ADHD in children. Method: A multidisciplinary group of experts in pediatric sleep medicine and ADHD convened in November 2010 to summarize the current literature, delineate knowledge gaps, and formulate recommendations regarding future research directions and priorities. Results: Six major research areas of interest were identified: (a) brain centers regulating sleep, arousal, and attention; (b) neurotransmitter systems involved in both sleep and attention regulation; (c) alterations of neural systems regulating sleep in ADHD; (d) phenotypic similarities between behavioral, mood, and cognitive manifestations of insufficient/disrupted sleep and ADHD; (e) hypoarousal and sleepiness in ADHD; and (f) external sleep–wake signals that affect sleep regulation in ADHD. Conclusion: An enhanced understanding of the complex mechanisms regulating sleep promotion, wakefulness, and attention may contribute to new insights regarding the core impairments in ADHD and lead to the development of new therapies.Keywords
This publication has 93 references indexed in Scilit:
- Longitudinal course of deficient emotional self-regulation CBCL profile in youth with ADHD: prospective controlled studyNeuropsychiatric Disease and Treatment, 2012
- PER2 rs2304672 Polymorphism Moderates Circadian-Relevant Reward Circuitry Activity in AdolescentsBiological Psychiatry, 2012
- Circadian rhythms and mood regulation: Insights from pre-clinical modelsEuropean Neuropsychopharmacology, 2011
- Sleep disturbances in children with attention-deficit/hyperactivity disorderExpert Review of Neurotherapeutics, 2011
- TNF-α Gene Polymorphisms and Excessive Daytime Sleepiness in Pediatric Obstructive Sleep ApneaThe Journal of Pediatrics, 2011
- Rapid Eye Movement Sleep Percentage in Children With Autism Compared With Children With Developmental Delay and Typical DevelopmentArchives of Pediatrics & Adolescent Medicine, 2010
- Circadian disruption and metabolic disease: Findings from animal modelsBest Practice & Research Clinical Endocrinology & Metabolism, 2010
- Stimulant Medication and Prefrontal Functional Connectivity During Working Memory in ADHDJournal of Attention Disorders, 2010
- Genome-wide gene expression profiling in children with non-obese obstructive sleep apneaSleep Medicine, 2009
- Reactivation of Hippocampal Ensemble Memories During SleepScience, 1994