Validation of a fully automated hippocampal segmentation method on patients with dementia
- 2 November 2007
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 29 (12), 1442-1449
- https://doi.org/10.1002/hbm.20480
Abstract
We describe a fully automated method for hippocampal segmentation. The method uses SPM5 ( http://www.fil.ion.ucl.ac.uk/spm/) software to segment the brain into grey/white matter, and spatially normalize the images to standard space. Grey matter pixels within a predefined hippocampal region in standard space are identified to segment the hippocampi. The method was validated on 36 subjects (9 each of Alzheimer's disease, dementia with Lewy bodies, vascular dementia, and healthy controls). The mean absolute difference in volume compared with manual segmentation was 11% (SD 9%). Linear regression between manual and automated volume gave V(auto) = V(manual) × 0.83 + 401 ml. The method provides an acceptable automated alternative to manual segmentation which may be of value in large studies. Hum Brain Mapp 2008.Keywords
This publication has 21 references indexed in Scilit:
- Anatomically constrained region deformation for the automated segmentation of the hippocampus and the amygdala: Method and validation on controls and patients with Alzheimer’s diseaseNeuroImage, 2007
- Atlas-based hippocampus segmentation in Alzheimer's disease and mild cognitive impairmentNeuroImage, 2005
- Changes in DWI and MRS associated with white matter hyperintensities in elderly subjectsNeurology, 2003
- Early diagnosis of alzheimer’s disease: contribution of structural neuroimagingNeuroImage, 2003
- Appearance-Based Segmentation of Medial Temporal Lobe StructuresNeuroImage, 2002
- Patterns of Cerebral Atrophy in Dementia with Lewy Bodies Using Voxel-Based MorphometryNeuroImage, 2002
- Whole Brain Segmentation: Automated Labeling of Neuroanatomical Structures in the Human BrainNeuron, 2002
- MRI volumetric study of dementia with Lewy bodiesNeurology, 2000
- The Human HippocampusPublished by Springer Science and Business Media LLC ,1998
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975