Evaluation of surface contamination with cyclophosphamide following simulated hazardous drug preparation activities using two closed-system products
Open Access
- 28 June 2010
- journal article
- Published by SAGE Publications in Journal of Oncology Pharmacy Practice
- Vol. 17 (1), 49-54
- https://doi.org/10.1177/1078155210374673
Abstract
Purpose. A preliminary investigation was conducted to evaluate and compare the effectiveness of two closed-system products in preventing contamination of typical pharmacy workplace surfaces with cyclophosphamide during simulated hazardous drug preparation activities in a controlled laboratory setting. Methods. Two separate trials simulating hazardous drug compounding using cyclophosphamide were performed with two different closed-system products. Prior to each trial, work area surfaces of the biological safety cabinet (BSC) workbench, the BSC airfoil and front grill, and the floor below the BSC were cleaned, and wipe samples were collected and analyzed to determine, if present, levels of cyclophosphamide. Following each trial, wipe samples were collected from the work area surfaces to determine the hazardous drug containment effectiveness of each closed-system product. Results. Cyclophosphamide was not detected on work area surfaces prior to each trial. Low levels were detected on the BSC workbench surface following both trials. Discussion. Based on the limited number of samples obtained during this preliminary study and the determination of the presence of the chemical of interest on the drug vials, no statistical evaluation was performed to compare the relative effectiveness of the two systems tested. Work practices and procedures regarding product operation may affect hazardous drug containment and worker safety. Further study and statistical analyses are needed.Keywords
This publication has 11 references indexed in Scilit:
- Preventing Occupational Exposures to Antineoplastic Drugs in Health Care SettingsCA: A Cancer Journal for Clinicians, 2006
- Comparison of surface contamination with cyclophosphamide and fluorouracil using a closed-system drug transfer device versus standard preparation techniquesAmerican Journal of Health-System Pharmacy, 2006
- Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: Results of three studiesAmerican Journal of Health-System Pharmacy, 2005
- Cytotoxic drug contamination on the outside of vials delivered to a hospital pharmacy.The Annals of Occupational Hygiene, 2003
- Effectiveness of a closed-system device in containing surface contamination with cyclophosphamide and ifosfamide in an i.v. admixture areaAmerican Journal of Health-System Pharmacy, 2002
- Surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United StatesAmerican Journal of Health-System Pharmacy, 1999
- Determination of cyclophosphamide in urine by gas chromatography—mass spectrometryJournal of Chromatography B: Biomedical Sciences and Applications, 1993
- Occupational exposure to antineoplastic agents at several departments in a hospitalInternationales Archiv für Arbeitsmedizin, 1992
- Detection of contamination with antineoplastic agents in a hospital pharmacy departmentInternational Journal of Clinical Pharmacy, 1992
- ASHP technical assistance bulletin on handling cytotoxic and hazardous drugs.1990