Maternal Pre-Pregnancy Obesity and Recurrent Wheezing in Early Childhood
- 1 September 2010
- journal article
- research article
- Published by Mary Ann Liebert Inc in Pediatric Allergy, Immunology, and Pulmonology
- Vol. 23 (3), 183-190
- https://doi.org/10.1089/ped.2010.0032
Abstract
A number of studies have linked obesity with asthma in adults and children. Few longitudinal studies have evaluated the effect of maternal pre-pregnancy obesity on either asthma or early childhood respiratory morbidity, and these have not been in urban, nonwhite populations. We sought to determine whether pre-pregnancy obesity was associated with recurrent wheezing in an urban, nonwhite population. This study includes 1,191 children from the Boston Birth Cohort (1998–present) followed prospectively to a mean age of 3.0 ± 2.4 years with study visits aligned with the pediatric primary care schedule. Multivariate logistic regression was used to evaluate the associations of maternal pre-pregnancy obesity (body mass index ≥30) with recurrent wheezing (≥4 lifetime episodes). Secondary outcomes included log-transformed cord-blood immunoglobulin E (Phadia), and physician diagnoses of eczema and food allergy. Pre-pregnancy obesity was present in 20.7% of mothers. Of the 1,191 children, 60 (5%) developed recurrent wheezing. Children of obese mothers had an increased risk of recurrent wheezing (adjusted odds ratio, 95% confidence interval: 3.51, 1.68–7.32). These associations persisted even after adjustment for fetal growth status. In contrast, maternal obesity was not associated with eczema or food allergy, and was inversely associated with log cord-blood immunoglobulin E (β, 95% confidence interval: −0.34, −0.66 to −0.02). In this predominantly urban, multiracial/ethnic birth cohort, maternal pre-pregnancy obesity was associated with an increased risk of recurrent wheezing. This association was not explained by fetal growth or increased atopy. Maternal pre-pregnancy obesity is a prevalent risk factor for respiratory morbidity in this urban, nonwhite population.Keywords
This publication has 53 references indexed in Scilit:
- Maternal dietary pattern during pregnancy is not associated with recurrent wheeze in childrenJournal of Allergy and Clinical Immunology, 2010
- Association of genetic ancestry with preterm delivery and related traits among African American mothersAmerican Journal of Obstetrics and Gynecology, 2009
- Maternal obesity in pregnancy and respiratory health in early childhoodPaediatric and Perinatal Epidemiology, 2009
- Folic acid supplements in pregnancy and early childhood respiratory healthArchives of Disease in Childhood, 2009
- Cord Blood Leptin and Adiponectin as Predictors of Adiposity in Children at 3 Years of Age: A Prospective Cohort StudyPEDIATRICS, 2009
- Accuracy of self-reported body weight, height and waist circumference in a Dutch overweight working populationBMC Medical Research Methodology, 2008
- Mediterranean Diet as a Protective Factor for Wheezing in Preschool ChildrenThe Journal of Pediatrics, 2008
- Prematurity, chorioamnionitis, and the development of recurrent wheezing: A prospective birth cohort studyJournal of Allergy and Clinical Immunology, 2008
- Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: new insights on G×E interactions and pathogenic pathwaysHuman Genetics, 2008
- Polymorphism in Maternal LRP8 Gene Is Associated with Fetal GrowthAmerican Journal of Human Genetics, 2006