Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament
Open Access
- 1 August 2007
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 75 (8), 3859-3867
- https://doi.org/10.1128/iai.00159-07
Abstract
Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ 28 promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.Keywords
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