Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Abstract

// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Jaclyn Quin1, 2, 11, Keefe T. Chan1, Jennifer R. Devlin1, 12, Donald P. Cameron1, 3, Jeannine Diesch1, 13, Carleen Cullinane1, Jessica Ahern1, Amit Khot1, Nadine Hein4, Amee J. George4, 5, 6, Katherine M Hannan2, 4, Gretchen Poortinga1, 7, Karen E Sheppard1, 2, 3, Kum Kum Khanna8, Ricky W. Johnstone1, 3, 5, Denis Drygin9, Grant A. McArthur1, 3, 5, 7, Richard B. Pearson1, 2, 3, 10, Elaine Sanij1, 5, *, Ross D Hannan1, 2, 3, 4, 6, 10, * 1Research Division, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria, Australia 2Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, Victoria, Australia 3Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia 4The John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia 5Department of Pathology, University of Melbourne, Parkville, Victoria, Australia 6School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia 7Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Victoria, Australia 8QIMR Berghofer Medical Research Institute, Qld, Australia 9Pimera Inc, San Diego, CA, USA 10Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 11Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, Sweden 12Institute for Molecular Medicine Finland, Biomedicum 2, Helsinki, Finland 13Josep Carreras Institute for Leukaemia Research (IJC), Campus ICO-HGTP, Badalona, Barcelona, Spain *These authors contributed equally to this work Correspondence to: Elaine Sanij, email: elaine.sanij@petermac.org Ross D Hannan, email: ross.hannan@anu.edu.au Keywords: RNA polymerase I, rDNA, CX-5461, nucleolar stress response, DNA damage signaling Received: March 17, 2016 Accepted: June 13, 2016 Published: July 06, 2016