Quantitative muscle ultrasound in Duchenne muscular dystrophy: A comparison of techniques
- 23 May 2014
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 51 (2), 207-213
- https://doi.org/10.1002/mus.24296
Abstract
Introduction Muscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound‐waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. Methods : We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2‐14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). Results : Both QBA and GSL were measured reliably (intraclass correlation ≥ 0.87) and were higher in DMD than controls (P < 0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho ≥ 0.47, P < 0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. Conclusions : QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD. Muscle Nerve 51 : 207–213, 2015Keywords
Funding Information
- National Institutes of Health (R01AR060850-02)
- Howard Hughes Medical Institute
- National Institutes of Health (R01 AR060850)
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