Increased Red Blood Cell Distribution Width Associates with Cancer Stage and Prognosis in Patients with Lung Cancer
Open Access
- 11 November 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (11), e80240
- https://doi.org/10.1371/journal.pone.0080240
Abstract
Red cell distribution width (RDW), one of many routinely examined parameters, shows the heterogeneity in erythrocyte size. We investigated the association of RDW levels with clinical parameters and prognosis of lung cancer patients. Clinical and laboratory data from 332 patients with lung cancer in a single institution were retrospectively studied by univariate analysis. Kaplan-Meier survival analysis and Cox proportional hazard models were used to examine the effect of RDW on survival. The RDW levels were divided into two groups: high RDW (>=15%), n=73 vs. low RDW, n=259 (ppp=0.002). In particular, the survival rates of stage I and II patients (n=141) were lower in the high RDW group (n=19) than in the low RDW group (n=122) (Wilcoxon test: pp=0.040). RDW is associated with several factors that reflect inflammation and malnutrition in lung cancer patients. Moreover, high levels of RDW are associated with poor survival. RDW might be used as a new and convenient marker to determine a patient’s general condition and to predict the mortality risk of lung cancer patients.This publication has 29 references indexed in Scilit:
- Red cell distribution width is a prognostic factor in severe sepsis and septic shockThe American Journal of Emergency Medicine, 2013
- Is Red Cell Distribution Width a Novel Biomarker of Breast Cancer Activity? Data From a Pilot StudyJournal of Clinical Medicine Research, 2013
- Clinical Usefulness of Measuring Red Blood Cell Distribution Width in Patients with Hepatitis BPLOS ONE, 2012
- Red Cell Distribution Width: A Novel Marker of Activity in Infl ammatory Bowel DiseaseGut and Liver, 2011
- Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literatureNutrition Journal, 2010
- Red cell distribution width in heart failure: Prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional stateAmerican Heart Journal, 2009
- Red Cell Distribution Width and Mortality in Older Adults: A Meta-analysisThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Red Blood Cell Distribution Width and the Risk of Death in Middle-aged and Older AdultsJAMA Internal Medicine, 2009
- Cancer-related inflammationNature, 2008
- Red Cell Distribution Width as a Novel Prognostic Marker in Heart Failure: Data From the CHARM Program and the Duke DatabankJournal of the American College of Cardiology, 2007