Lithium: Long‐term effects on the kidney
- 23 August 1987
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 76 (2), 193-198
- https://doi.org/10.1111/j.1600-0447.1987.tb02883.x
Abstract
Renal lithium clearance was investigated in 44 patients treated with lithium for an average of 8 years as part of a functional-morphological follow-up study including a kidney biopsy. The average renal lithium clearance was 0.36 ml/s (= 21.6 ml/min). A significant correlation with age, sex and glomerular filtration rate was seen, whereas no significant relationship with urine volume, lithium treatment regimen and histopathological biopsy variables was found. The results were compared with the same renal functional tests obtained from a control group consisting of 26 patients with affective disorders never treated with lithium. The control group had a lower urine output, but no significant difference in lithium clearance was observed. In conclusion, renal lithium clearance is a specific investigation, which may provide valuable baseline information on glomerulo-tubular function in patients before and during prophylactic lithium treatment.Keywords
This publication has 21 references indexed in Scilit:
- Renal Function of Patients in Long-term Treatment With Lithium Citrate Alone or in Combination With Neuroleptics and Antidepressant DrugsArchives of General Psychiatry, 1986
- Lithium dosage in the elderly: A study with matched age groupsJournal of Affective Disorders, 1985
- Renal lithium clearance as a rapid and accurate predictor of maintenance doseAmerican Journal of Psychiatry, 1982
- Determination of lithium-induced impairment of distal water reabsorptionJournal of Psychiatric Research, 1981
- Renal function in lithium and non-lithium treated patients with affective disordersActa Psychiatrica Scandinavica, 1980
- Renal Function and Biopsy in Patients on Lithium-Therapy*Pharmacopsychiatry, 1980
- Renal Concentrating Capacity in Long‐Term Lithium Treatment and after Withdrawal of LithiumActa Medica Scandinavica, 1980
- Lithium treatment and kidney function A SURVEY OF 237 PATIENTS IN LONG-TERM TREATMENTActa Psychiatrica Scandinavica, 1979
- Renal function after long-term treatment with lithium.BMJ, 1979
- Chronic renal lesions following long-term treatment with lithiumKidney International, 1977