Improvements in cholesterol efflux capacity of HDL and adiponectin contribute to mitigation in cardiovascular disease risk after bariatric surgery in a cohort with morbid obesity
Open Access
- 17 April 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetology & Metabolic Syndrome
- Vol. 13 (1), 1-11
- https://doi.org/10.1186/s13098-021-00662-3
Abstract
Bariatric surgery can alleviate cardiovascular risk via effects on cardiovascular disease (CVD) risk factors such as diabetes mellitus, hypertension, and dyslipidemia. Our study aimed to assess the cholesterol efflux capacity (CEC) of HDL as a negative risk factor for CVD in individuals with obesity and identify the factors associated with improvement in CEC 3 months following bariatric surgery. We recruited 40 control individuals (mean BMI of 22.2 kg/m2) and 56 obese individuals (mean BMI of 45.9 kg/m2). The biochemical parameters, inflammatory status and CEC of HDL was measured for the obese individuals before bariatric surgery and at 3 months after surgery. The CEC was measured using a cell-based cholesterol efflux system of BODIPY-cholesterol-labelled THP-1 macrophages. A significant reduction in BMI (− 17%, p < 0.001), resolution of insulin sensitivity (HOMA2-IR = − 23.4%, p = 0.002; Adipo IR = − 16%, p = 0.009) and inflammation [log resistin = − 6%, p = 0.07] were observed 3 months post-surgery. CEC significantly improved 3 months after surgery [Pre: 0.91 ± 0.13; Post: 1.02 ± 0.16; p = 0.001] despite a decrease in HDL-C levels. The change in CEC correlated with the change in apo A-I (r = 0.39, p = 0.02) and adiponectin levels (r = 0.35, p = 0.03). The results suggest that improvements in CEC, through improvement in adipose tissue health in terms of adipokine secretion and insulin sensitivity could be an important pathway in modulating obesity-related CVD risk.Keywords
Funding Information
- Department of Science and Technology, Ministry of Science and Technology, Government of India (EMR/2016/006018)
This publication has 45 references indexed in Scilit:
- Gastric bypass and banding equally improve insulin sensitivity and β cell functionJCI Insight, 2012
- High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetesLipids in Health and Disease, 2012
- HDL dysfunction in diabetes: causes and possible treatmentsExpert Review of Cardiovascular Therapy, 2012
- A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterolJournal of Lipid Research, 2011
- Cholesterol Efflux Capacity, High-Density Lipoprotein Function, and AtherosclerosisThe New England Journal of Medicine, 2011
- Rosuvastatin 20 mg restores normal HDL-apoA-I kinetics in type 2 diabetesJournal of Lipid Research, 2009
- Adiponectin deficiency suppresses ABCA1 expression and ApoA‐I synthesis in the liverFEBS Letters, 2007
- Long-Term Mortality after Gastric Bypass SurgeryThe New England Journal of Medicine, 2007
- Adiponectin accelerates reverse cholesterol transport by increasing high density lipoprotein assembly in the liverBiochemical and Biophysical Research Communications, 2007
- Abdominal obesity and metabolic syndromeNature, 2006