Transfer of extracellular vesicles during immune cell‐cell interactions
- 19 December 2012
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 251 (1), 125-142
- https://doi.org/10.1111/imr.12013
Abstract
The transfer of molecules between cells during cognate immune cell interactions has been reported, and recently a novel mechanism of transfer of proteins and genetic material such as small RNA between T cells and antigen‐presenting cells (APCs) has been described, involving exchange of extracellular vesicles (EVs) during the formation of the immunological synapse (IS). EVs, a term that encompasses exosomes and microvesicles, has been implicated in cell‐cell communication during immune responses associated with tumors, pathogens, allergies, and autoimmune diseases. This review focuses on EV transfer as a mechanism for the exchange of molecules during immune cell‐cell interactions.Keywords
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