Predicting methylation status of CpG islands in the human brain
Open Access
- 12 July 2006
- journal article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 22 (18), 2204-2209
- https://doi.org/10.1093/bioinformatics/btl377
Abstract
Motivation: Over 50% of human genes contain CpG islands in their 5′-regions. Methylation patterns of CpG islands are involved in tissue-specific gene expression and regulation. Mis-epigenetic silencing associated with aberrant CpG island methylation is one mechanism leading to the loss of tumor suppressor functions in cancer cells. Large-scale experimental detection of DNA methylation is still both labor-intensive and time-consuming. Therefore, it is necessary to develop in silico approaches for predicting methylation status of CpG islands.Keywords
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