Lung and brain damage in preterm newborns, and their association with gestational age, prematurity subgroup, infection/inflammation and long term outcome
- 16 February 2005
- journal article
- review article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 112 (s1), 4-9
- https://doi.org/10.1111/j.1471-0528.2005.00576.x
Abstract
Compared with those born at term, preterm newborns are at an increased risk of short term disorders of the lung (bronchopulmonary dysplasia; BPD) and the brain (white matter damage; WMD), and of long term developmental and pulmonary dysfunctions. Although all of these adverse outcomes are associated with low gestational age, brain, but not lung, damage appears to be associated with the prematurity subgroup [spontaneous preterm labour and/or preterm prelabour rupture of membranes (PPROM) vs pregnancy-induced hypertension (PIH)]. Part of the association between brain damage and prematurity subgroup might be due to a differential exposure of members of these subgroups to perinatal infection/inflammation. There is a lack of studies evaluating the association of antenatal and perinatal risk factors with late childhood pulmonary dysfunction among those born during the second trimester. In this paper we discuss the complexities that paediatricians, perinatologists and perinatal epidemiologists face as they try to understand the contributions of factors associated with preterm birth to neonatal and childhood disorders.Keywords
This publication has 61 references indexed in Scilit:
- The wealth of information conveyed by gestational ageThe Journal of Pediatrics, 2005
- Intraventricular Hemorrhage and Periventricular Leukomalacia in Preterm InfantsObstetrics & Gynecology, 2004
- Respiratory symptoms and lung function in relation to atopy in children born pretermPediatric Pulmonology, 2003
- Neuroimaging in the preterm infantMental Retardation and Developmental Disabilities Research Reviews, 2002
- Changing panorama of cerebral palsy in Sweden. VIII. Prevalence and origin in the birth year period 1991–94Acta Paediatrica, 2001
- Changing panorama of cerebral palsy in Sweden. VIII. Prevalence and origin in the birth year period 1991–94Acta Paediatrica, 2001
- White matter disorders of prematurity: Association with intraventricular hemorrhage and ventriculomegalyThe Journal of Pediatrics, 1999
- Characteristics of cranial ultrasound white-matter echolucencies that predict disability: a reviewDevelopmental Medicine and Child Neurology, 1999
- Ventriculomegaly, delayed myelination, white matter hypoplasia, and “periventricular” leukomalacia: How are they related?Pediatric Neurology, 1996
- Does the LOSS of Plocentol Hormones Contribute to Neuro‐developmental Disabilities in Preterm infants?Developmental Medicine and Child Neurology, 1994