Genomic Analysis at the Single-Cell Level
- 15 December 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 45 (1), 431-445
- https://doi.org/10.1146/annurev-genet-102209-163607
Abstract
Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.Keywords
This publication has 103 references indexed in Scilit:
- Microbial environments confound antibiotic efficacyNature Chemical Biology, 2011
- Whole-genome molecular haplotyping of single cellsNature Biotechnology, 2011
- Single-cell NF-κB dynamics reveal digital activation and analogue information processingNature, 2010
- Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq AnalysisCell Stem Cell, 2010
- Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genesNature, 2010
- Variability in gene expression underlies incomplete penetranceNature, 2010
- Sequencing genomes from single cells by polymerase cloningNature Biotechnology, 2006
- Generation of a functional mammary gland from a single stem cellNature, 2006
- Purification and unique properties of mammary epithelial stem cellsNature, 2006
- Real-Time Kinetics of Gene Activity in Individual BacteriaCell, 2005