Lanthanides in magnetic resonance imaging
Top Cited Papers
- 2 May 2006
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Chemical Society Reviews
- Vol. 35 (6), 557-571
- https://doi.org/10.1039/b516376p
Abstract
Magnetic Resonance Imaging is perhaps the most important and prominent technique in diagnostic clinical medicine and biomedical research. Its success and development as an imaging technique has been aided by the characteristics of contrast agents that enhance signal intensities and improve specificity. Gadolinium(III) remains the dominant starting material for contrast agent design but other lanthanide ions (and other oxidation states i.e. +2) are also being increasingly investigated as alternatives to gadolinium(III) within laboratory conditions. This critical review provides a concise summary of the MRI-active gadolinium(III) complexes to date – their pros and cons, an outline of contrast agents based on other lanthanide ions (e.g. europium, dysprosium), and directs the reader to newer, more speculative areas of lanthanide-containing contrast agent design.Keywords
This publication has 100 references indexed in Scilit:
- Cytotoxicity of Colloidal CdSe and CdSe/ZnS NanoparticlesNano Letters, 2004
- Synthesis of a bifunctional monophosphinic acid DOTA analogue ligand and its lanthanide(iii) complexes. A gadolinium(iii) complex endowed with an optimal water exchange rate for MRI applicationsOrganic & Biomolecular Chemistry, 2004
- Thermal shaping of shell-crosslinked (SCK) nanoparticles, facilitated by nanoconfinement of fluid-like coresJournal of Materials Chemistry, 2003
- Improved molecular imaging contrast agent for detection of human thrombusMagnetic Resonance in Medicine, 2003
- From monomers to micelles: investigation of the parameters influencing proton relaxivityJBIC Journal of Biological Inorganic Chemistry, 2002
- Lanthanide Podates with Programmed Intermolecular Interactions: Luminescence Enhancement through Association with Cyclodextrins and Unusually Large Relaxivity of the Gadolinium Self-AggregatesJournal of the American Chemical Society, 2000
- Gadolinium-Loaded Nanoparticles: New Contrast Agents for Magnetic Resonance ImagingJournal of the American Chemical Society, 2000
- Second Coordination Sphere Water Molecules and Relaxivity of Gadolinium(III) Complexes: Implications for MRI Contrast AgentsEuropean Journal of Inorganic Chemistry, 2000
- Prototropic and Water-Exchange Processes in Aqueous Solutions of Gd(III) ChelatesAccounts of Chemical Research, 1999
- Synthesis and Solvent Enhanced Relaxation Property of Water-Soluble Endohedral MetallofullerenolsFullerene Science and Technology, 1997