Size Matters: Sequential Mutations in Tumorigenesis May Reflect the Stochastic Effect of Mutagen Target Sizes
- 1 October 2011
- journal article
- Published by SAGE Publications in Genes & Cancer
- Vol. 2 (10), 927-931
- https://doi.org/10.1177/1947601911436200
Abstract
We tallied the number of possible mutant amino acids in proteins thought to be inactivated early in tumorigenesis and in proteins thought to be inactivated late in tumorigenesis, respectively. Proteins thought to be inactivated early in tumorigenesis, on average, have a greater number of alternative, mutant possibilities, which raises the possibility that the sequential order of mutations associated with cancer development reflects the random chance, throughout life, of a mutagen inactivating a larger versus a smaller target. The hypothesis that the temporal order of genetic changes in cancer reflects mutagen target sizes leads to novel considerations of 1) the mechanisms of the acquisition of cancer hallmarks and 2) cancer screening strategies.Keywords
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