A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides
- 24 February 2012
- journal article
- review article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 51 (12), 2834-2848
- https://doi.org/10.1002/anie.201106628
Abstract
We describe herein our recent explorations in the field of isonitrile chemistry. An array of broadly useful coupling methodologies has been developed for the formation of peptidyl and glycopeptidyl amide bonds. We further describe the application of these methods to the syntheses of complex systems, including the cyclic peptide cyclosporine A, constrained peptide systems, and heterocycles.Keywords
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