The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions
Top Cited Papers
Open Access
- 8 November 2014
- journal article
- review article
- Published by American Diabetes Association in Diabetes Care
- Vol. 37 (12), 3336-3344
- https://doi.org/10.2337/dc14-0574
Abstract
The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, race/ethnicity, sex, and diabetes type. Prevalence increased significantly from 2001 to 2009 for both type 1 and type 2 diabetes in most age, sex, and race/ethnic groups. SEARCH has also established a longitudinal cohort to assess the natural history and risk factors for acute and chronic diabetes-related complications as well as the quality of care and quality of life of persons with diabetes from diagnosis into young adulthood. Many youth with diabetes, particularly those from low-resourced racial/ethnic minority populations, are not meeting recommended guidelines for diabetes care. Markers of micro- and macrovascular complications are evident in youth with either diabetes type, highlighting the seriousness of diabetes in this contemporary cohort. This review summarizes the study methods, describes key registry and cohort findings and their clinical and public health implications, and discusses future directions.Keywords
This publication has 101 references indexed in Scilit:
- Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009JAMA, 2014
- Prevalence of Diabetes in U.S. Youth in 2009: The SEARCH for Diabetes in Youth StudyDiabetes Care, 2014
- Implications for Glucose Measures in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications StudyDiabetes, 2013
- Population-based survey of the prevalence of type 1 and type 2 diabetes in school children in Philadelphia (费城学龄儿童1型与2型糖尿病患病率基于人口的调查)Journal of Diabetes, 2013
- Incidence of Childhood Type 1 and Non-Type 1 Diabetes Mellitus in a Diverse Population: The Chicago Childhood Diabetes Registry, 1994 to 2003Journal of Pediatric Endocrinology and Metabolism, 2007
- The Burden of Diabetes Mellitus Among US Youth: Prevalence Estimates From the SEARCH for Diabetes in Youth StudyPEDIATRICS, 2006
- SEARCH for Diabetes in Youth: a multicenter study of the prevalence, incidence and classification of diabetes mellitus in youthControlled Clinical Trials, 2004
- Capture-recapture method in the epidemiology of type 2 diabetes: a contribution from the Verona Diabetes Study.Diabetes Care, 2000
- Increasing prevalence of Type II diabetes in American Indian childrenDiabetologia, 1998
- Increased incidence of non-insulin-dependent diabetes mellitus among adolescentsThe Journal of Pediatrics, 1996