Corticostriatal functional connectivity predicts transition to chronic back pain
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Open Access
- 1 July 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 15 (8), 1117-1119
- https://doi.org/10.1038/nn.3153
Abstract
In a longitudinal brain imaging study, patients with subacute back pain were followed over the course of 1 year. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain. The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.Keywords
This publication has 47 references indexed in Scilit:
- Music Enhances Autobiographical Memory in Mild Alzheimer's DiseaseEducational Gerontology, 2012
- Brain Morphological Signatures for Chronic PainPLOS ONE, 2011
- Pain Characteristic Differences Between Subacute and Chronic Back PainThe Journal of Pain, 2011
- Large-scale automated synthesis of human functional neuroimaging dataNature Methods, 2011
- Does the insula tell our brain that we are in pain?Pain, 2011
- Pain and the brain: Specificity and plasticity of the brain in clinical chronic painPain, 2011
- Dissociating the Neural Correlates of Intra-Item and Inter-Item Working-Memory BindingPLOS ONE, 2010
- Predicting Value of Pain and Analgesia: Nucleus Accumbens Response to Noxious Stimuli Changes in the Presence of Chronic PainNeuron, 2010
- Working Memory for Conjunctions Relies on the Medial Temporal LobeJournal of Neuroscience, 2006
- CONFABULATION, EXECUTIVE FUNCTIONS, AND SOURCE MEMORY IN ALZHEIMER'S DISEASECognitive Neuropsychology, 1999