Regulate to reduce chemical mixture risk
Top Cited Papers
- 20 July 2018
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 361 (6399), 224-226
- https://doi.org/10.1126/science.aat9219
Abstract
Humans and wildlife are continuously exposed to multiple chemicals from different sources and via different routes, both simultaneously and in sequence. Scientific evidence for heightened toxicity from such mixtures is mounting, yet regulation is lagging behind. Ensuring appropriate regulation of chemical mixture risks will require stronger legal stimuli as well as close integration of different parts of the regulatory systems in order to meet the data and testing requirements for mixture risk assessment.This publication has 11 references indexed in Scilit:
- Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryosScientific Reports, 2017
- Examining the feasibility of mixture risk assessment: A case study using a tiered approach with data of 67 pesticides from the Joint FAO/WHO Meeting on Pesticide Residues (JMPR)Food and Chemical Toxicology, 2015
- Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessmentCurrent Opinion in Pharmacology, 2014
- Mixtures of Chemical Pollutants at European Legislation Safety Concentrations: How Safe Are They?Toxicological Sciences, 2014
- Dispelling urban myths about default uncertainty factors in chemical risk assessment – sufficient protection against mixture effects?Environmental Health, 2013
- Toxicity on the luminescent bacterium Vibrio fischeri (Beijerinck). II: Response to complex mixtures of heterogeneous chemicals at low levels of individual componentsEcotoxicology and Environmental Safety, 2012
- Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS frameworkRegulatory Toxicology and Pharmacology, 2011
- Therapeutic dose as the point of departure in assessing potential health hazards from drugs in drinking water and recycled municipal wastewaterRegulatory Toxicology and Pharmacology, 2011
- Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessmentCritical Reviews in Toxicology, 2011
- Structure—activity relationships and additivity in fish toxicities of environmental pollutantsEcotoxicology and Environmental Safety, 1980