Antioxidant Activity ofMyristica malabaricaExtracts and Their Constituents
- 28 July 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 53 (17), 6912-6918
- https://doi.org/10.1021/jf050861x
Abstract
The 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay of the ether, methanol, and aqueous extracts of the spice Myristica malabarica (rampatri) revealed the methanol extract to possess the best antioxidant activity. Column chromatography of the methanol extract led to the isolation of a new 2-acylresorcinol and four known diarylnonanoids of which the diarylnonanoid, malabaricone C, showed the maximum DPPH scavenging activity. Malabaricone C could prevent both Fe(II)- and 2,2‘-azobis(2-amidinopropane)dihydrochloride-induced lipid peroxidation (LPO) of rat liver mitochondria more efficiently than curcumin. The anti-LPO activity of malabaricone C was attributed to its better radical scavenging and Fe(II) chelation capacities. The superior activity of malabaricone C was rationalized by a systematic structure−activity correlation of the results obtained with the structurally related diarylnonanoids and curcumin. Malabaricone C also prevented the γ-ray-induced damage of pBR322 plasmid DNA in a concentration-dependent manner. The radioprotective activity was found to correlate with its •OH radical scavenging property, which matched well with that of d-mannitol. Keywords: Antioxidant; active principle; malabaricone C; Myristica malabaricaKeywords
This publication has 18 references indexed in Scilit:
- Effects of curcumin and curcumin derivatives on mitochondrial permeability transition poreFree Radical Biology & Medicine, 2004
- A mechanistic study on the nuclease activities of some hydroxystilbenesBioorganic & Medicinal Chemistry, 2004
- The Kinetics of Copper-Induced LDL Oxidation Depend upon Its Lipid Composition and Antioxidant ContentBiochemical and Biophysical Research Communications, 2000
- Reactive Nitrogen Species in Colon CarcinogenesisAntioxidants and Redox Signaling, 1999
- DNA Cleavage Induced by Oxyl Radicals Generated in the Photosensitized Decomposition of Fatty Ester Hydroperoxides Derived from Oleic and Linoleic AcidArchives of Biochemistry and Biophysics, 1998
- Reactions of oxyl radicals with DNAFree Radical Biology & Medicine, 1995
- [19] Ferrylmyoglobin: Formation and chemical reactivity toward electron-donating compoundsMethods in Enzymology, 1994
- Record High-Temperature Superconductors ClaimedScience, 1987
- Absence of the cotton dust/bract antigen in house dust, clean cotton fibers and cottonseed hulls and proteinsJournal of Oil & Fat Industries, 1981
- THE ANTIOXIDANT PROPERTIES OF NATURAL SPICESa,bJournal of Food Science, 1952