In vivohigh-resolution 3D photoacoustic imaging of superficial vascular anatomy
- 23 January 2009
- journal article
- research article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 54 (4), 1035-1046
- https://doi.org/10.1088/0031-9155/54/4/014
Abstract
The application of a photoacoustic imaging instrument based upon a Fabry-Perot polymer film ultrasound sensor to imaging the superficial vasculature is described. This approach provides a backward mode-sensing configuration that has the potential to overcome the limitations of current piezoelectric based detection systems used in superficial photoacoustic imaging. The system has been evaluated by obtaining non-invasive images of the vasculature in human and mouse skin as well as mouse models of human colorectal tumours. These studies showed that the system can provide high-resolution 3D images of vascular structures to depths of up to 5 mm. It is considered that this type of instrument may find a role in the clinical assessment of conditions characterized by changes in the vasculature such as skin tumours and superficial soft tissue damage due to burns, wounds or ulceration. It may also find application in the characterization of small animal cancer models where it is important to follow the tumour vasculature over time in order to study its development and/or response to therapy.Keywords
This publication has 19 references indexed in Scilit:
- In vivo photoacoustic imaging of subcutaneous vasculature and vascular anomalies in small animalsThe European Physical Journal Applied Physics, 2008
- Predicting Response to Radioimmunotherapy from the Tumor Microenvironment of Colorectal CarcinomasCancer Research, 2007
- Photoacoustic Doppler Effect from Flowing Small Light-Absorbing ParticlesPhysical Review Letters, 2007
- The frequency-dependent directivity of a planar fabry-perot polymer film ultrasound sensorIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 2007
- Portable real-time photoacoustic microscopyPublished by SPIE-Intl Soc Optical Eng ,2007
- Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentrationPhysics in Medicine & Biology, 2006
- Pulsed near-infrared laser diode excitation system for biomedical photoacoustic imagingOptics Letters, 2006
- 2D imaging of ultrasound fields using CCD array to map output of Fabry-Perot polymer film sensorElectronics Letters, 2006
- Transparent ITO coated PVDF transducer for optoacoustic depth profilingOptics Communications, 2005
- Temporal backward projection of optoacoustic pressure transients using Fourier transform methodsPhysics in Medicine & Biology, 2001