Easily synthesized novel biodegradable copolyesters with adjustable properties for biomedical applications
- 4 April 2012
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Soft Matter
- Vol. 8 (20), 5466-5476
- https://doi.org/10.1039/c2sm25308a
Abstract
Current compositions of biodegradable aliphatic polyesters experience a number of limitations associated with the difficulty of customizing mechanical, physicochemical, and biological properties for different biomedical applications. In this study, we propose a new class of multiblock copolyesters made using butylene succinate (BS) and triethylene succinate (TES). In particular, four copolyesters with the same chemical composition but different block lengths – P(BS18TES18), P(BS9TES9), P(BS4TES4), and P(BS2TES2) – were synthesized by reactive blending. Physicochemical characterization (DSC, WAXS, tensile tests, WCA, hydrolysis experiments) demonstrated that, by simply varying block length, it is possible to control polymer crystallinity, thermal and mechanical properties, wettability, and degradation rate. Copolymers displayed different stiffness, depending on the crystallinity degree, a tunable range of degradation rates, and different surface hydrophilicity. In vitro drug release and cell culture experiments were performed to evaluate the potential of these new copolyesters in the biomedical field. In particular, fluorescein isothiocyanate (FITC) was used as a model molecule to study the release profile of small molecules, and polymer cytocompatibility and fibronectin absorption capability were assessed. Depending on comonomer distribution, the polyesters are capable of releasing FITC in a tailorable manner. Moreover, the newly developed biomaterials are not cytotoxic and they are able to absorb proteins and, consequently, to tailor cell adhesion according to their surface hydrophilicity.This publication has 39 references indexed in Scilit:
- Cellulose-Based Dual Graft Molecular Brushes as Potential Drug Nanocarriers: Stimulus-Responsive Micelles, Self-Assembled Phase Transition Behavior, and Tunable Crystalline MorphologiesBiomacromolecules, 2009
- Purification of human plasma fibronectin using immobilized gelatin and Arg affinity chromatographyNature Protocols, 2008
- in vitro Evaluation of Biodegradable Poly(butylene succinate) as a Novel BiomaterialMacromolecular Bioscience, 2005
- A molecular modeling study of the effect of surface chemistry on the adsorption of a fibronectin fragment spanning the 7–10th type III repeatsJournal of Biomedical Materials Research Part A, 2004
- Synthesis and characterization of poly(butylene terephthalate)‐co‐poly(butylene succinate)‐block‐poly(ethylene glycol) segmented block copolymersPolymer International, 2003
- Melting behavior of poly(butylene succinate) during heating scan by DSCJournal of Polymer Science Part B: Polymer Physics, 1999
- Transesterification and crystallization behavior of poly(butylene succinate)/poly(butylene terephthalate) block copolymersJournal of Polymer Science Part A: Polymer Chemistry, 1998
- Probing surface microheterogeneity of poly(ether urethanes) in an aqueous environmentLangmuir, 1991
- Copolyesters. I. Sequence distribution of poly(butylene terephthalate‐co‐adipate) copolyesters determined by 400 MHz NMRJournal of Applied Polymer Science, 1990
- Role of Fibronectin in Adhesion, Migration, and MetastasisCancer Investigation, 1989