The renaissance of GSK3
Top Cited Papers
- 1 October 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 2 (10), 769-776
- https://doi.org/10.1038/35096075
Abstract
Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic intervention.Keywords
This publication has 68 references indexed in Scilit:
- Intestinal polyposis in mice with a dominant stable mutation of the beta -catenin geneThe EMBO Journal, 1999
- A GSK3‐binding peptide from FRAT1 selectively inhibits the GSK3‐catalysed phosphorylation of Axin and β‐cateninFEBS Letters, 1999
- Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3βCurrent Biology, 1998
- Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neuronsFEBS Letters, 1997
- Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cellsCurrent Biology, 1996
- Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase BNature, 1995
- The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitroFEBS Letters, 1994
- Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule bindingNeuron, 1993
- Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tauFEBS Letters, 1992
- Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinaseNeuroscience Letters, 1992