The gene for human transforming growth factor α is on the short arm of chromosome 2
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 42 (1-2), 94-98
- https://doi.org/10.1159/000132258
Abstract
Transforming growth factor α is a polypeptide growth factor that participates in the reversible transformation of cells in vitro and is secreted by many transformed cell lines. It also shares sequence and functional homologies with epidermal growth factor. Working with a cloned cDNA probe (λhTGFl-10) and derivatives, we have mapped this gene (TGFA) to 2p13 with the use of somatic cell hybrids and in situ hybridization. This is the same region involved in the 2;8 translocations of Burkitt lymphoma. Such a rearrangement could orient c-myc (8q24) adjacent to TGFA, resulting in activation of one or both of these genes.Keywords
This publication has 3 references indexed in Scilit:
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- Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.Proceedings of the National Academy of Sciences of the United States of America, 1980