Histamine 2 receptor-mediated immunomodulation in the mouse. I. Immunomodulation by the H2 agonist tolazoline.
- 1 March 1979
- journal article
- Vol. 35 (3), 470-7
Abstract
Tolazoline, a drug used in the treatment of hypertension, has been described as a typical H2 agonist. In this study possible immunomodulating properties of tolazoline were investigated. A single injection of tolazoline 1 day before immunization caused an effect on delayed hypersensitivity that depended on the antigen dose. The response to 10(5) and 10(6) sheep red blood cells (SRBC) was decreased, whereas the response to 10(9) SRBC was enhanced. Administration of tolazoline 4 days after immunization predominantly affected the humoral response. The IgM response was inhibited in favour of the IgG response. Low doses of tolazoline, given to animals simultaneously with the elicitation for delayed hypersensitivity, lead to a more severe inflammation. The possible involvement of suppressor cells and vessels in tolazoline action is discussed. The application of tolazoline in the immunotherapy of human cancer is suggested.This publication has 31 references indexed in Scilit:
- Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.The Journal of Experimental Medicine, 1978
- Histamine suppression of human lymphocyte responses to mitogensCellular Immunology, 1978
- ACQUIRED TOLERANCE TO DINITROCHLOROBENZENE REVERSED BY CIMETIDINEThe Lancet, 1977
- EFFECT OF CIMETIDINE ON PANCREATIC EXOCRINE SECRETIONThe Lancet, 1977
- Histamine receptor-bearing peripheral T lymphocytes in patients with allergiesJournal of Allergy and Clinical Immunology, 1977
- Selective Display of Histamine Receptors on LymphocytesScience, 1977
- The separation and reactivity in vitro of a subpopulation of human lymphocytes which bind histamine. Correlation of histamine reactivity with cellular maturationCellular Immunology, 1976
- Studies on the maturation of thymus stem cells The effects of catecholamines, histamine and peptide hormones on the expression of T cell alloantigensEuropean Journal of Immunology, 1976
- In vitro correction of antigen-induced immune suppression: Effects of histamine, dibutyryl cyclic AMP and cholera enterotoxinCellular Immunology, 1974
- REGULATION OF ANTIBODY RESPONSE BY CELLS EXPRESSING HISTAMINE RECEPTORSThe Journal of Experimental Medicine, 1972