Increased CSF osmolarity reversibly induces hydrocephalus in the normal rat brain
Open Access
- 1 January 2012
- journal article
- Published by Springer Science and Business Media LLC in Fluids and Barriers of the CNS
- Vol. 9 (1), 13
- https://doi.org/10.1186/2045-8118-9-13
Abstract
Hydrocephalus is a central nervous system (CNS) disorder characterized by the abnormal accumulation of cerebrospinal fluid (CSF) in cerebral ventricles, resulting in their dilatation and associated brain tissue injury. The pathogenesis of hydrocephalus remains unclear; however, recent reports suggest the possible involvement of abnormal osmotic gradients. Here we explore the kinetics associated with manipulating CSF osmolarity on ventricle volume (VV) in the normal rat brain.Keywords
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