Voltage-Gated Calcium Channels and Idiopathic Generalized Epilepsies
Open Access
- 1 July 2006
- journal article
- review article
- Published by American Physiological Society in Physiological Reviews
- Vol. 86 (3), 941-966
- https://doi.org/10.1152/physrev.00002.2006
Abstract
The idiopathic generalized epilepsies encompass a class of epileptic seizure types that exhibit a polygenic and heritable etiology. Advances in molecular biology and genetics have implicated defects in certain types of voltage-gated calcium channels and their ancillary subunits as important players in this form of epilepsy. Both T-type and P/Q-type channels appear to mediate important contributions to seizure genesis, modulation of network activity, and genetic seizure susceptibility. Here, we provide a comprehensive overview of the roles of these channels and associated subunits in normal and pathological brain activity within the context of idiopathic generalized epilepsy.Keywords
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