The Manitoba IBD Cohort Study: A Population-Based Study of the Prevalence of Lifetime and 12-Month Anxiety and Mood Disorders
- 1 August 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Gastroenterology
- Vol. 103 (8), 1989-1997
- https://doi.org/10.1111/j.1572-0241.2008.01980.x
Abstract
BACKGROUNDG AND AIMS: ven the impact of anxiety and mood disorders on health, it is important to consider these disorders in persons with inflammatory bowel disease (IBD). We assessed the prevalence of anxiety and mood disorders in a population-based IBD cohort. A structured diagnostic interview was administered to participants in the cohort (N = 351), and rates were compared to age-, gender-, and region-matched controls drawn from a national survey (N = 779). A comparison of lifetime prevalence suggests higher rates of panic, generalized anxiety, and obsessive-compulsive disorders and major depression and lower rates of social anxiety and bipolar disorders in the IBD sample than in national samples in the United States and New Zealand. Direct comparisons with matched controls (with data available for three anxiety disorders) found lifetime prevalence (IBD vs controls) as follows: social anxiety disorder lower in IBD (6% vs 11%, OR 0.52, 95% CI 0.32–0.85), panic disorder not significantly different (8.0% vs 4.7%, OR 1.59, 95% CI 0.96–2.63), agoraphobia without panic not significantly different (1.1% vs 0.6%, OR 1.44, 95% CI 0.37–5.55), and major depression higher (27.2% vs 12.3%, OR 2.20, 95% CI 1.64–2.95). Comparing IBD respondents with and without lifetime anxiety or mood disorder, those with a disorder reported lower quality of life and earlier onset of IBD symptoms and there was a trend toward earlier IBD diagnosis. Clinicians should be aware of the increased prevalence of depression and possibly other anxiety disorders in persons with IBD as these disorders may influence response to treatment and quality of life.Keywords
This publication has 35 references indexed in Scilit:
- Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey ReplicationArchives of General Psychiatry, 2005
- Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey ReplicationArchives of General Psychiatry, 2005
- Long-Term Medical Conditions and Major Depression: Strength of Association for Specific Conditions in the General PopulationThe Canadian Journal of Psychiatry, 2005
- Comorbid Mental Disorders Account for the Role Impairment of Commonly Occurring Chronic Physical Disorders: Results From the National Comorbidity SurveyJournal of Occupational and Environmental Medicine, 2003
- Impact of major depression on chronic medical illnessJournal of Psychosomatic Research, 2002
- A Review of Studies of Psychiatric Factors in Crohn's Disease: Etiologic ImplicationsAnnals of Clinical Psychiatry, 1994
- The relation of ulcerative colitis to psychiatric factors: a review of findings and methodsAmerican Journal of Psychiatry, 1990
- Psychiatric illness in patients with inflammatory bowel disease.Gut, 1987
- A study of the association between Crohn's disease and psychiatric illnessGastroenterology, 1984
- A controlled study of the association between ulcerative colitis and psychiatric diagnosesDigestive Diseases and Sciences, 1982