Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations
- 1 September 1995
- journal article
- case report
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 14 (1), 43-50
- https://doi.org/10.1002/gcc.2870140108
Abstract
Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X;1)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above‐mentioned subset of RCC. Using FISH in conjunction with X‐specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2.Keywords
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