Migraine in women: the role of hormones and their impact on vascular diseases
Open Access
- 26 February 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in The Journal of Headache and Pain
- Vol. 13 (3), 177-189
- https://doi.org/10.1007/s10194-012-0424-y
Abstract
Migraine is a predominantly female disorder. Menarche, menstruation, pregnancy, and menopause, and also the use of hormonal contraceptives and hormone replacement treatment may influence migraine occurrence. Migraine usually starts after menarche, occurs more frequently in the days just before or during menstruation, and ameliorates during pregnancy and menopause. Those variations are mediated by fluctuation of estrogen levels through their influence on cellular excitability or cerebral vasculature. Moreover, administration of exogenous hormones may cause worsening of migraine as may expose migrainous women to an increased risk of vascular disease. In fact, migraine with aura represents a risk factor for stroke, cardiac disease, and vascular mortality. Studies have shown that administration of combined oral contraceptives to migraineurs may further increase the risk for ischemic stroke. Consequently, in women suffering from migraine with aura caution should be deserved when prescribing combined oral contraceptives.Keywords
This publication has 140 references indexed in Scilit:
- Headache and migraine during pregnancy and puerperium: the MIGRA-studyThe Journal of Headache and Pain, 2011
- Characteristics of Menstrual vs Nonmenstrual Migraine: A Post Hoc, Within‐Woman Analysis of the Usual‐Care Phase of a Nonrandomized Menstrual Migraine Clinical TrialHeadache: The Journal of Head and Face Pain, 2010
- Self-reported menstrual migraine in the general populationThe Journal of Headache and Pain, 2010
- Comorbid neuropathologies in migraine: an update on cerebrovascular and cardiovascular aspectsThe Journal of Headache and Pain, 2008
- Vascular Actions of Estrogens: Functional ImplicationsPharmacological Reviews, 2008
- Comorbid neuropathologies in migraineThe Journal of Headache and Pain, 2006
- Disability Associated With Headaches Occurring Inside and Outside the Menstrual Period in Those With Migraine: A General Practice StudyHeadache: The Journal of Head and Face Pain, 2005
- Randomized Trial of Estrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal WomenJAMA, 1998
- Estrogen Increases Endothelial Nitric Oxide by a Receptor Mediated SystemBiochemical and Biophysical Research Communications, 1995
- Opioid Control of the Hypothalamus-Pituitary-Adrenal Axis Cyclically Fails in Menstrual MigraineCephalalgia, 1990