Magnetic resonance metrics to evaluate the effect of therapy in amyotrophic lateral sclerosis: the experience with edaravone
Open Access
- 1 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Neurologie
- Vol. 268 (9), 1-9
- https://doi.org/10.1007/s00415-021-10495-9
Abstract
Background Edaravone was approved as a new treatment for amyotrophic lateral sclerosis (ALS), although there are different opinions on its effectiveness. Magnetic resonance (MRI) measures appear promising as diagnostic and prognostic indicators of disease. However, published studies on MRI using to monitor treatment efficacy in ALS are lacking. Purpose The objective of this study was to investigate changes in brain MRI measures in patients treated with edaravone. Methods Thirteen ALS patients assuming edaravone (ALS-EDA) underwent MRI at baseline (T0) and after 6 months (T6) to measure cortical thickness (CT) and fractional anisotropy (FA) of white matter (WM) tracts. MRI data of ALS-EDA were compared at T0 with those of 12 control subjects (CS), and at T6 with those of 11 ALS patients assuming only riluzole (ALS-RIL), extracted from our ALS cohort using a propensity-score-matching. A longitudinal MRI analysis was performed in ALS-EDA between T6 and T0. Results At T0, ALS-EDA showed a cortical widespread thinning in both hemispheres, particularly in the bilateral precentral gyrus, and a reduction of FA in bilateral corticospinal tracts, in comparison to CS. Thinning in bilateral precentral cortex and significant widespread reduction of FA in several WM tracts were observed in ALS-EDA at T6 compared to T0. At T6, no significant differences in MRI measures of ALS-EDA versus ALS-RIL were found. Conclusions Patients treated with edaravone showed progression of damage in the motor cortex and several WM tracts, at a six-month follow-up. Moreover, this study showed no evidence of a difference between edaravone and riluzole.Funding Information
- Universita degli Studi di Bari Aldo Moro
This publication has 44 references indexed in Scilit:
- Cortical Thinning and Clinical Heterogeneity in Amyotrophic Lateral SclerosisPLOS ONE, 2013
- Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosisBMC Neuroscience, 2012
- Sample size estimates for well‐powered cross‐sectional cortical thickness studiesHuman Brain Mapping, 2012
- Surgery and Brain Atrophy in Cognitively Normal Elderly Subjects and Subjects Diagnosed with Mild Cognitive ImpairmentAnesthesiology, 2012
- Avoiding asymmetry-induced bias in longitudinal image processingNeuroImage, 2011
- Highly accurate inverse consistent registration: A robust approachNeuroImage, 2010
- Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosisNeurology, 2010
- A comparison between voxel-based cortical thickness and voxel-based morphometry in normal agingNeuroImage, 2009
- Threshold-free cluster enhancement: Addressing problems of smoothing, threshold dependence and localisation in cluster inferenceNeuroImage, 2009
- A longitudinal diffusion tensor MRI study of the cervical cord and brain in amyotrophic lateral sclerosis patientsJournal of Neurology, Neurosurgery & Psychiatry, 2008