Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo
Open Access
- 8 January 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cancer Chemotherapy and Pharmacology
- Vol. 66 (5), 881-888
- https://doi.org/10.1007/s00280-009-1234-z
Abstract
Voreloxin is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits topoisomerase II, inducing site-selective DNA damage. Voreloxin is in clinical studies, as a single agent and in combination with cytarabine, for the treatment of acute myeloid leukemia (AML). The preclinical studies reported here were performed to investigate the activity of voreloxin alone and in combination with cytarabine, in support of the clinical program.Keywords
This publication has 34 references indexed in Scilit:
- Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase IIPLOS ONE, 2010
- Voreloxin, a First-in-Class Anticancer Quinolone Derivative, in Relapsed/Refractory Solid Tumors: A Report on Two Dosing SchedulesClinical Cancer Research, 2010
- Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging AgentDrug Metabolism and Disposition, 2008
- Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination StudiesPharmacological Reviews, 2006
- Evaluation of Combination ChemotherapyClinical Cancer Research, 2004
- Acute Myeloid LeukemiaHematology, 2004
- Hematology of the MousePublished by Elsevier BV ,2004
- The roles of FLT3 in hematopoiesis and leukemiaBlood, 2002
- Structure and Function of Bone Marrow Hemopoiesis: Mechanisms of Response to Ionizing Radiation ExposureCancer Biotherapy & Radiopharmaceuticals, 2002
- Cellular resistance to anthracyclinesGeneral Pharmacology: The Vascular System, 1996