Posterior brain in fetuses with open spina bifida at 11 to 13 weeks
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Open Access
- 28 December 2010
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 31 (1), 103-106
- https://doi.org/10.1002/pd.2632
Abstract
Objective To measure the changes in the posterior fossa in first-trimester fetuses with open spina bifida (OSB). Methods The brain stem diameter and brain stem to occipital bone (BSOB) diameter were measured in stored images of the mid-sagittal view of the fetal face at 11+0 to 13+6 weeks from 30 fetuses with OSB and 1000 normal controls. Results In the control group, the brain stem and BSOB diameter increased significantly with crown-rump length (CRL) and the brain stem to BSOB ratio decreased. In the spina bifida group, the brain stem diameter was above the 95th percentile of the control group in 29 (96.7%) cases, the BSOB diameter was below the 5th percentile in 26 (86.7%) and the brain stem to BSOB ratio was above the 95th percentile in all cases. Conclusions At 11 to 13 weeks the majority of fetuses with OSB have measurable abnormalities in the posterior brain. Copyright © 2010 John Wiley & Sons, Ltd.Keywords
Funding Information
- Fetal Medicine Foundation (1037116)
This publication has 6 references indexed in Scilit:
- Assessment of intracranial translucency (IT) in the detection of spina bifida at the 11–13‐week scanUltrasound in Obstetrics & Gynecology, 2009
- Prenatal diagnosis of open and closed spina bifidaUltrasound in Obstetrics & Gynecology, 2006
- UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestationThe Lancet, 1998
- Evaluation of the lemon and banana signs in one hundred thirty fetuses with open spina bifidaAmerican Journal of Obstetrics and Gynecology, 1990
- ULTRASOUND SCREENING FOR SPINA BIFIDA: CRANIAL AND CEREBELLAR SIGNSThe Lancet, 1986
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986