Active Surveillance with Selective Delayed Intervention Using PSA Doubling Time for Good Risk Prostate Cancer

Abstract

Good risk prostate cancer, defined as patients with a Gleason score of 6 or less, PSA10 years, and 20% had a PSA DT>100 years. The majority of patients in this study remain on surveillance. The approach of active surveillance with selective delayed intervention based on PSA DT represents a practical compromise between radical therapy for all (which results in overtreatment for patients with indolent disease), and watchful waiting with palliative therapy only (which results in undertreatment for those with aggressive disease).