99Tcm–DTPA for the measurement of glomerular filtration rate

Abstract
Comparison of the blood clearances of 51Cr-EDTA and 99Tcm-DTPA in a series of 45 patients with a wide range of glomerular filtration rates [GFR], showed that there was a good correlation between the estimates of GFR obtained using the 2 chelates simultaneously. The single-injection, single-exponential method of GFR estimation was used, with a correction factor of 0.964 for 99Tcm-DTPA, which gave a relationship of GFRCr = 2.3 + GFRTcml/min with a correlation coefficient of 0.99. 99Tcm-DTPA is a suitable agent for the estimation of GFR in the evaluation of renal disease.