PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM
Open Access
- 1 March 1960
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 46 (3), 302-311
- https://doi.org/10.1073/pnas.46.3.302
Abstract
A protein with specific nerve-growth stimulating properties has been purified from the submaxillary gland of the mouse. Upon examination in an ultracentrifuge, only one component was detectable with a sedimentation constant of 4.33 S. The protein, when injected into mice, resulted in a marked increase in the protein, RNA, and DNA contents of the sympathetic chain ganglia. A rabbit antiserum to the growth factor was prepared and was found to inhibit the effect of the growth factor in tissue culture and to have specific neurocytotoxic activity when injected into a variety of mammalian species.This publication has 11 references indexed in Scilit:
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