Relationships between Plasma β-Amyloid Peptide 1–42 and Atherosclerotic Risk Factors in Community-Based Older Populations
- 21 November 2003
- journal article
- Published by S. Karger AG in Gerontology
- Vol. 49 (6), 374-379
- https://doi.org/10.1159/000073765
Abstract
Background: Recent studies have suggested that atherosclerosis contributes to the development of dementia of the Alzheimer’s type (DAT). Convenient and valid biochemical markers of DAT are needed to control risk factors for this disease. The aims of the present study were thus (1) to determine the distribution of plasma β-amyloid peptide1–42 (Aβ1–42) levels in an older population and (2) to investigate factors correlating with plasma levels of this amyloid peptide. Our data support the hypothesis that atherosclerosis plays a role in the pathogenesis of DAT. Methods: 759 Japanese community residents participated in a municipal medical health evaluation; a subset of 280 was selected at random for the measurement of physiological, psychosocial and life-style variables, together with the analysis of blood specimens for cell counts, hematocrit, Aβ1–42, and other biochemical markers. Results: Log-transformed plasma Aβ1–42 concentrations showed a Gaussian distribution. Quartiles of log10 (Aβ1–42) concentrations correlated significantly with age categories, but not with other sociopsychological and life-style variables. Plasma Aβ1–42 was significantly correlated with systolic and diastolic blood pressure (DBP; r = 0.19, p = 0.002 and r = 0.16, p = 0.007, respectively), pulse pressure (r = 0.13, p = 0.036), total cholesterol (r = 0.15, p = 0.011), log10 (triacyl glycerol) (r = 0.14, p = 0.021), and log10 (hemoglobin A1c) [log10 (HbA1c)] (r = 0.14, p = 0.020). Stepwise multiple regression analysis showed significant independent effects of DBP, and log10 (HbA1c) on plasma Aβ1–42 concentrations. Conclusions: Our findings suggest that conventional atherosclerotic risk factors are associated with plasma Aβ1–42 levels. This observation may be important in the detection and prevention of DAT.Keywords
This publication has 20 references indexed in Scilit:
- The Journal of Neurology and the European familyZeitschrift für Neurologie, 2000
- Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid StimulationScience, 1999
- Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neuronsProceedings of the National Academy of Sciences, 1998
- Vascular Risks and Incident Dementia: Results from a Cohort Study of the Very OldDementia and Geriatric Cognitive Disorders, 1998
- Brain infarction and the clinical expression of Alzheimer disease. The Nun StudyPublished by American Medical Association (AMA) ,1997
- Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's diseaseNature Medicine, 1996
- RAGE and amyloid-β peptide neurotoxicity in Alzheimer's diseaseNature, 1996
- 15-year longitudinal study of blood pressure and dementiaThe Lancet, 1996
- Induction of Alzheimer-like β-Amyloid Immunoreactivity in the Brains of Rabbits with Dietary CholesterolExperimental Neurology, 1994
- Measurement of competence: reliability and validity of the TMIG Index of CompetenceArchives of Gerontology and Geriatrics, 1991