PHYSIOLOGIC DETERMINANTS OF THE ANOREXIA OF AGING: Insights from Animal Studies
- 1 July 2002
- journal article
- review article
- Published by Annual Reviews in Annual Review of Nutrition
- Vol. 22 (1), 417-438
- https://doi.org/10.1146/annurev.nutr.22.120301.071049
Abstract
The anorexia of aging is a syndrome characterized by unexplained losses in food intake and body weight that occur near the end of life. Proposed etiologies cover a wide range of biological and psychological conditions. The observation of this phenomenon in older laboratory animals suggests that physiological changes play a significant causal role. Research on the neurochemical control of energy balance has received much attention in recent years, and age-related alterations in the neuropeptidergic effectors of food intake have been implicated in the anorexia of aging. This review provides an update on putative mechanisms underlying this dysregulation of feeding during advanced age.Keywords
This publication has 118 references indexed in Scilit:
- Influence of aging on gastric emptying of liquids, small intestine transit, and fecal output in ratsExperimental Gerontology, 1996
- Static Theories in a Dynamic World: A Glucodynamic Theory of Food IntakeObesity Research, 1996
- Effects of pyruvate and lactate on food intake in rat strains sensitive and resistant to dietary obesityPhysiology & Behavior, 1996
- Peripheral 3-hydroxybutyrate and food intake in a model of dietary-fat induced obesity: Effect of vagotomyPhysiology & Behavior, 1995
- Impaired insulin release in aging rats: Metabolic and ionic eventsCellular and Molecular Life Sciences, 1993
- Age-related changes in cortico-releasing factor, somatostatin, neuropeptide Y, methionine enkephalin and β-endorphin in specific rat brain areasBrain Research, 1992
- Continuous intraventricular infusion of neuropeptide Y evokes episodic food intake in satiated female rats: Effects of adrenalectomy and cholecystokininPeptides, 1988
- Age-related and diurnal changes in met5-enk-arg6-phe7 and met5-enkephalin contents of pituitary and rat brain structuresLife Sciences, 1984
- The effects of aging on opioid modulation of feeding in ratsLife Sciences, 1983
- Age-related changes in central nervous system enkephalins and substance PLife Sciences, 1981