Deep brain stimulation in Tourette's syndrome: Two targets?
- 6 February 2006
- journal article
- case report
- Published by Wiley in Movement Disorders
- Vol. 21 (5), 709-713
- https://doi.org/10.1002/mds.20816
Abstract
In this report, we describe the effects of bilateral thalamic stimulation in one patient and of bilateral pallidal stimulation in another patient. Both patients suffered from intractable Tourette’s syndrome (TS). Any conservative treatment had failed or had been stopped because of unbearable side effects in the 2 patients. In both cases, there was no comorbidity except for associated behavioral symptoms (compulsions). Electrodes were implanted at the level of the medial part of the thalamus (centromedian nucleus, the substantia periventricularis, and the nucleus ventro‐oralis internus) in one patient and in the posteroventral part of the globus pallidus internus (GPi) in the other patient. In both cases, deep brain stimulation (DBS) resulted in a substantial reduction of tics and compulsions. These data show that bilateral DBS of the thalamus as well as of the GPi can have a good effect on tics and behavioral symptoms in patients suffering from intractable TS. © 2006 Movement Disorder SocietyKeywords
This publication has 7 references indexed in Scilit:
- Surgery in Tourette syndromeMovement Disorders, 2004
- Deep brain stimulation of the thalamus can influence penile erectionInternational Journal Of Impotence Research, 2004
- Chronic bilateral thalamic stimulation: a new therapeutic approach in intractable Tourette syndromeJournal of Neurosurgery, 2003
- Tourette's syndromeThe Lancet, 2002
- Basal ganglia dysfunction in Tourette’s syndrome: a new hypothesisPediatric Neurology, 2001
- Stereotactic treatment of Gilles de la Tourette syndrome by high frequency stimulation of thalamusThe Lancet, 1999
- Revision of the Padua Inventory of obsessive compulsive disorder symptoms: Distinctions between worry, obsessions, and compulsionsBehaviour Research and Therapy, 1996