Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a histological and histomorphometric study in the Goettingen miniature pig
- 26 March 2008
- journal article
- Published by Wiley in Clinical Oral Implants Research
- Vol. 19 (5), 522-529
- https://doi.org/10.1111/j.1600-0501.2007.01494.x
Abstract
The aim of this study was to test the hypothesis that recombinant human growth and differentiation factor-5 (rhGDF-5) enhances bone formation in sinus floor augmentations in miniature pigs. The maxillary sinus floors in 12 adult female Goettingen minipigs were augmented with beta-tricalcium phosphate (beta-TCP) on one side. The contralateral test side was augmented using two concentrations of rhGDF-5 (400 microg rhGDF-5/g beta-TCP; 800 microg rhGDF-5/g beta-TCP) delivered on beta-TCP (six animals each). One dental implant was inserted into each sinus floor augmentation. After 4 and 12 weeks, histological and histomorphometric assessment of non-decalcified histological specimens was performed. The results showed significantly higher mean values of volume density (VD) of newly formed bone using the concentration of 400 microg/g beta-TCP (22.8%) compared with the respective control (8%) after 4 weeks (P=0.05). The bone-to-implant contact rates were also significantly enhanced after 4 weeks between test sites (400 microg: 41.9%; 800 microg: 40.6%) and control sites (400 microg: 7.8%; 800 microg: 16.4%) (400 microg: P=0.024; 800 microg: P=0.048). It is concluded that rhGDF-5 delivered on beta-TCP significantly enhanced early bone formation compared with beta-TCP alone in sinus lift procedures in miniature pigs.Keywords
This publication has 35 references indexed in Scilit:
- Osseointegration of Osseotite® and machined‐surfaced titanium implants in membrane‐covered critical‐sized defects: a histologic and histometric study in dogsClinical Oral Implants Research, 2006
- Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb®) for bone regeneration in the reconstructive surgery of the jawsInternational Journal of Oral & Maxillofacial Surgery, 2006
- Bone regeneration using recombinant human bone morphogenetic protein-2 (rhBMP-2) in alveolar defects of primate mandiblesBritish Journal of Oral and Maxillofacial Surgery, 2001
- Inductive activity of recombinant human growth and differentiation factor-5Biochemical Society Transactions, 2000
- Sinus floor augmentation with simultaneous placement of dental implants using a combination of deproteinized bone xenografts and recombinant human osteogenic protein‐l. A histometric study in miniature pigs.Clinical Oral Implants Research, 1999
- Histomorphometrical analysis of bone formed in human maxillary sinus floor elevations grafted with OP‐1 device, demineralized bone matrix or autogenous bone. Comparison with non‐grafted sites in a series of case reports.Clinical Oral Implants Research, 1999
- Recombinant Human Growth/Differentiation Factor 5 Stimulates Mesenchyme Aggregation and Chondrogenesis Responsible for the Skeletal Development of LimbsGrowth Factors, 1996
- Experimental study by fluorescence microscopy and microangiography of remodeling and regeneration of bone inside alloplastic contour augmentationsInternational Journal of Oral & Maxillofacial Surgery, 1994
- Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamilyNature, 1994
- Studies in the Design and Analysis of Dental Experiments: 13. Balanced Incomplete Block DesignJournal of Dental Research, 1970