The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology
Top Cited Papers
Open Access
- 19 November 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Psychiatry
- Vol. 15 (12), 1128-1139
- https://doi.org/10.1038/mp.2010.4
Abstract
A fundamental function of the brain is to evaluate the emotional and motivational significance of stimuli and to adapt behaviour accordingly. The IMAGEN study is the first multicentre genetic-neuroimaging study aimed at identifying the genetic and neurobiological basis of individual variability in impulsivity, reinforcer sensitivity and emotional reactivity, and determining their predictive value for the development of frequent psychiatric disorders. Comprehensive behavioural and neuropsychological characterization, functional and structural neuroimaging and genome-wide association analyses of 2000 14-year-old adolescents are combined with functional genetics in animal and human models. Results will be validated in 1000 adolescents from the Canadian Saguenay Youth Study. The sample will be followed up longitudinally at the age of 16 years to investigate the predictive value of genetics and intermediate phenotypes for the development of frequent psychiatric disorders. This review describes the strategies the IMAGEN consortium used to meet the challenges posed by large-scale multicentre imaging–genomics investigations. We provide detailed methods and Standard Operating Procedures that we hope will be helpful for the design of future studies. These include standardization of the clinical, psychometric and neuroimaging-acquisition protocols, development of a central database for efficient analyses of large multimodal data sets and new analytic approaches to large-scale genetic neuroimaging analyses.Keywords
This publication has 62 references indexed in Scilit:
- The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophreniaMolecular Psychiatry, 2009
- Common variants conferring risk of schizophreniaNature, 2009
- Why do many psychiatric disorders emerge during adolescence?Nature Reviews Neuroscience, 2008
- Genome-wide association studies: potential next steps on a genetic journeyHuman Molecular Genetics, 2008
- Genetics of addictions: strategies for addressing heterogeneity and polygenicity of substance use disordersPhilosophical Transactions B, 2008
- Serotonin Transporter (5-HTTLPR) Genotype and Amygdala Activation: A Meta-AnalysisBiological Psychiatry, 2008
- Substantia nigra/ventral tegmental reward prediction error disruption in psychosisMolecular Psychiatry, 2007
- Gene–gene interaction associated with neural reward sensitivityProceedings of the National Academy of Sciences of the United States of America, 2007
- The endophenotype concept in psychiatric geneticsPsychological Medicine, 2006
- Gene–environment interactions in psychiatry: joining forces with neuroscienceNature Reviews Neuroscience, 2006