Reactions between ribonucleoside derivatives and formaldehyde in ethanol solution

Abstract

2′,3′-O-Isopropylidene-adenosine, -cytidine, and -guanosine, (2a), (3a), and (4a), respectively react with formaldehyde in ethanol solution to give the corresponding N-ethoxymethyl derivatives, (2b), (3b), and (4b), respectively in good yields.