Effect of exercise-induced arterial hypoxemia on quadriceps muscle fatigue in healthy humans
- 1 February 2006
- journal article
- clinical trial
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 290 (2), R365-R375
- https://doi.org/10.1152/ajpregu.00332.2005
Abstract
The effect of exercise-induced arterial hypoxemia (EIAH) on quadriceps muscle fatigue was assessed in 11 male endurance-trained subjects [peak O2uptake (V̇o2 peak) = 56.4 ± 2.8 ml·kg−1·min−1; mean ± SE]. Subjects exercised on a cycle ergometer at ≥90% V̇o2 peakto exhaustion (13.2 ± 0.8 min), during which time arterial O2saturation (SaO2) fell from 97.7 ± 0.1% at rest to 91.9 ± 0.9% (range 84–94%) at end exercise, primarily because of changes in blood pH (7.183 ± 0.017) and body temperature (38.9 ± 0.2°C). On a separate occasion, subjects repeated the exercise, for the same duration and at the same power output as before, but breathed gas mixtures [inspired O2fraction (FiO2) = 0.25–0.31] that prevented EIAH (SaO2= 97–99%). Quadriceps muscle fatigue was assessed via supramaximal paired magnetic stimuli of the femoral nerve (1–100 Hz). Immediately after exercise at FiO20.21, the mean force response across 1–100 Hz decreased 33 ± 5% compared with only 15 ± 5% when EIAH was prevented ( P < 0.05). In a subgroup of four less fit subjects, who showed minimal EIAH at FiO20.21 (SaO2= 95.3 ± 0.7%), the decrease in evoked force was exacerbated by 35% ( P < 0.05) in response to further desaturation induced via FiO20.17 (SaO2= 87.8 ± 0.5%) for the same duration and intensity of exercise. We conclude that the arterial O2desaturation that occurs in fit subjects during high-intensity exercise in normoxia (−6 ± 1% ΔSaO2from rest) contributes significantly toward quadriceps muscle fatigue via a peripheral mechanism.Keywords
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