Heparan sulfate proteoglycans: Coordinators of multiple signaling pathways during chondrogenesis
- 25 March 2004
- journal article
- review article
- Published by Wiley in Birth Defects Research Part C: Embryo Today: Reviews
- Vol. 72 (1), 69-88
- https://doi.org/10.1002/bdrc.20005
Abstract
Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed. Birth Defects Research (Part C) 72:69–88, 2004.Keywords
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