Androgen Receptor and Mechanism of Androgen Action
- 1 January 1993
- journal article
- review article
- Published by Taylor & Francis Ltd in Annals of Medicine
- Vol. 25 (1), 83-89
- https://doi.org/10.3109/07853899309147863
Abstract
Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner. The present overview describes the structurally important domains of the receptor protein, and discusses several aspects in the structure-function relationship, using naturally occurring receptor mutants in androgen insensitivity patients or experimental animals as examples. In addition, characteristics of androgen receptor expressed in a heterologous system are described, and their potential usefulness in specific molecular studies discussed.This publication has 30 references indexed in Scilit:
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